Human PLTP Alexa Fluor™ Plus 680-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # AF5109AFP680

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AF5109AFP680-100UG
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Key Product Details

Species Reactivity

Human

Applications

Knockout Validated, Western Blot

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Polyclonal Sheep IgG

View all PLTP Antibodies »

Product Specifications

Specificity

Detects human PLTP in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant mouse PLTP is observed.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications for Human PLTP Alexa Fluor™ Plus 680-conjugated Antibody

Application
Recommended Usage

Knockout Validated

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Background: PLTP

PLTP (phospholipid transfer protein) is a 75-81 kDa, secreted glycoprotein member of the BPI/LBP family of proteins. It is expressed by multiple cell types, circulates bound to HDL, and mediates the transfer of phospholipids and cholesterol from apoB-containing lipoproteins to HDL. Mature human PLTP is 476 amino acids (aa) in length. It contains an N-terminal lipid transfer domain and a C-terminal HDL-binding domain; there is one essential intrachain disulfide bond (Cys146-Cys185). There are four potential PLTP splice variants. Two show alternate start sites at Met21 and Met89. Two others demonstrate aa substitutions; one shows a one aa (Lys) substitution for aa 110-162, and a second shows a four aa substitution for the N-terminal 35 amino acids. Over aa 18-493, human PLTP shares 92% and 83% aa identity with porcine and mouse PLTP, respectively.

Long Name

Phospholipid Transfer Protein

Alternate Names

HDLCQ9, Lipid transfer protein II, phospholipid transfer protein

Entrez Gene IDs

5360 (Human); 18830 (Mouse); 296371 (Rat)

Gene Symbol

PLTP

UniProt

P55058 (Human)

Additional PLTP Products

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Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human PLTP Alexa Fluor™ Plus 680-conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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