Human PIEZO2 Alexa Fluor™ Plus 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB11559AFP488

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FAB11559AFP488-100UG
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 1081503

View all PIEZO2 Antibodies »

Product Specifications

Immunogen

PIEZO2 containing synthetic peptide

Specificity

Detects a synthetic peptide specific for Piezo2 around amino acid 2115 in Direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human PIEZO2 Alexa Fluor™ Plus 488-conjugated Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PIEZO2

PIEZO2 is an 318 kDa mechanosensitive nonselective cation channel, found in cell types that typically respond to physical touch. PIEZO2 is an essential mechanotransducer for touch, proprioception, and interoception.  PIEZO2 is important for aspects of breathing, bladder control, blood pressure regulation and many other processes since it is expressed in several classes of jugular and nodose ganglia neurons. Loss of function of PIEZO2 results in profound lack of proprioception and is diagnosed as a rare disease caused PIEZO2 deficiency syndrome.

References

  1. Wu J, Lewis AH, Grandl J. Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels. Trends Biochem Sci. 2017 Jan;42(1):57-71. doi: 10.1016/j.tibs.2016.09.004. Epub 2016 Oct 12. PMID: 27743844; PMCID: PMC5407468. 
  2. Szczot M, Nickolls AR, Lam RM, Chesler AT. The Form and Function of PIEZO2. Annu Rev Biochem. 2021 Jun 20;90:507-534. doi: 10.1146/annurev-biochem-081720-023244. PMID: 34153212; PMCID: PMC8794004.

Long Name

PIEZO2

Alternate Names

C18orf30, C18orf58, DA3, DA5, DAIPT, FAM38B, FAM38B2, family with sequence similarity 38, member A pseud, family with sequence similarity 38, member B2, HsT748, HsT771, MWKS, piezo-type mechanosensitive ion channel component

Entrez Gene IDs

63895 (Human); 667742 (Mouse); 307380 (Rat)

Gene Symbol

Q9H5I5

UniProt

Q9H5I5 (Human)

Additional PIEZO2 Products

Product Documents

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human PIEZO2 Alexa Fluor™ Plus 488-conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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