Human Phospho-BRCA1 (S1423) Alexa Fluor® 700-conjugated Antibody

Name: Human Phospho-BRCA1 (S1423) Alexa Fluor® 700-conjugated Antibody
Brand: R&D Systems
SKU: AF1386N

R&D Systems, part of Bio-Techne | Catalog # AF1386N

Submit a review

Product Datasheet / COA

Key Product Details

Species Reactivity:	Human
Immunogen:	Phosphopeptide containing human BRCA1 S1423 site
Applications:	Immunocytochemistry/ Immunofluorescence, Western Blot
Label:	Alexa Fluor 700 (Excitation=675-700 nm, Emission=723 nm)
Specificity:	Detects human Phospho-BRCA1 when phosphorylated at S1423 in Western blots.

View Full Technical Details for Human Phospho-BRCA1 (S1423) Alexa Fluor® 700-conjugated Antibody

Technical Data
Citations / Reviews

Applications

	Recommended Concentration	Sample
Western Blot	Optimal dilution of this antibody should be experimentally determined.
Immunocytochemistry	Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application.

Formulation, Preparation and Storage

Purification	Antigen Affinity-purified
Formulation	Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background: BRCA1

The BRCA1 (BReast CAncer gene 1) tumor suppressor protein has many reported functions. In addition to mediating signal transduction in DNA damage and repair responses, BRCA1 regulates transcriptional activity and assists in the preservation of chromosomal stability. BRCA1 is phosphorylated at S1423 by the ATM (Ataxia‑Telangiectasia Mutated) and ATR (ATM-and Rad3-related) protein kinases in response to genotoxic stress.

Item	Value
Long Name	Breast Cancer 1
Entrez Gene IDs	672 (Human); 12189 (Mouse); 497672 (Rat)
Alternate Names	BRCA1, BRCAI, EC 6.3.2, EC 6.3.2.-, IRIS, PNCA4, PSCP, breast and ovarian cancer susceptibility protein 1, breast and ovarian cancer sususceptibility protein, breast cancer 1, early onset, breast cancer type 1 susceptibility protein, subunit 1

Customer Reviews

There are currently no reviews for this product. Be the first to review Human Phospho-BRCA1 (S1423) Alexa Fluor® 700-conjugated Antibody and earn rewards!

Have you used Human Phospho-BRCA1 (S1423) Alexa Fluor® 700-conjugated Antibody?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review

Product Documents

Product Datasheets

Download Product Datasheets