Human PADI2 Alexa Fluor™ Plus 488-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF7257AFP488
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Immunohistochemistry
Label
Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)
Antibody Source
Polyclonal Sheep IgG
Product Specifications
Specificity
Detects human PADI2 in direct ELISAs.
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Applications for Human PADI2 Alexa Fluor™ Plus 488-conjugated Antibody
Application
Recommended Usage
Immunohistochemistry
Optimal dilution of this antibody should be experimentally determined.
Background: PADI2
PADI2 (Protein-arginine deiminase type 2; also PAD2, PDI2 and PAD-H19) is a 72-76 kDa member of the PAD family of proteins. It is widely expressed, being found in macrophages, astrocytes, select neurons, skeletal muscle and bronchial epithelial cells, and keratinocytes. PADI2 catalyzes the Ca++-dependent conversion of guanidino groups (NH2-C[=NH]-NH−) to ureido groups (NH2-C[=O]-NH-) on peptidylArg, a posttranslational process known as citrullination. Human PADI2 is 665 amino acids (aa) in length. It contains an N-terminal PAD domain (aa 1-114), a middle PAD-M domain (aa 116-274), and a catalytic region (aa 279-665). Over aa 1-115, human PADI2 shares 90% aa sequence identity with mouse PADI2.
Long Name
Peptidyl Arginine Deiminase type II
Alternate Names
PAD-H19, PAD2, PDI2, Peptidylarginine Deiminase II
Gene Symbol
PADI2
UniProt
Additional PADI2 Products
Product Specific Notices for Human PADI2 Alexa Fluor™ Plus 488-conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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