Human Nucleoredoxin Alexa Fluor™ Plus 680-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # AF5719AFP680

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AF5719AFP680-100UG
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Polyclonal Goat IgG

View all Nucleoredoxin Antibodies »

Product Specifications

Specificity

Detects endogenous human Nucleoredoxin in Western blots.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Background: Nucleoredoxin

Nucleoredoxin (NRX; also known as NXN and Red-1) is a 51‑55 kDa member of the thioredoxin (TXR) family of proteins. It is widely expressed, and exists in both the nucleus and cytoplasm of cells where it regulates two pathways. In the nucleus, NRX may act as a transcription factor in the Wnt-pathway; a stable (reduced) NRX binds to DVL, thereby blocking downstream Wnt/ beta-catenin signaling. It also binds to PP2A subunits PP2AC and PP2AA, generating an active PP2A complex. Human NRX is 435 amino acids (aa) in length and contains a TXR domain (aa 167‑321) that shows a WCPPC catalytic site, and a substrate recognition PDI-b’ region (aa 312‑427). There are three potential isoform variants. Over amino acids 131‑435, human NRX shares 99% aa identity with mouse NRX.

Alternate Names

NRN, NRX, NXN, TRG-4

Entrez Gene IDs

64359 (Human); 18230 (Mouse); 360577 (Rat)

Gene Symbol

NXN

UniProt

Q6DKJ4 (Human)

Additional Nucleoredoxin Products

Product Documents

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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