Human/Mouse ZIC1 Alexa Fluor™ Plus 680-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # AF4978AFP680

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AF4978AFP680-100UG
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunohistochemistry, Western Blot, Immunocytochemistry

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Polyclonal Goat IgG

View all ZIC1 Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human ZIC1

Specificity

Detects human and mouse ZIC1 in direct ELISAs and Western blots.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: ZIC1

ZIC1 (zinc-finger protein of the cerebellum 1) is a 54-60 kDa member of the GLI C2H2-type Zn-finger protein family. It is expressed in embryonic sclerotome and dermomyotome and in postmitotic cerebellar granule cells and retinal ganglion cells. ZIC1 is a transcription factor that promotes ApoE expression and blocks activation of Math1, allowing for neuroblast multiplication at the expense of differentiation. Human ZIC1 is 447 amino acids (aa) in length. It contains N-terminal poly Ala and His segments, followed by five C2H2-type Zn-fingers. Although the first two are atypical (aa 225-296), the last three Zn-fingers (aa 302-384) are canonical and bind to GLI1, 2 and 3. There is one potential alternate start site at Met353. Over aa 1-198, human ZIC1 is 99% aa identical to mouse ZIC1.

Long Name

Zic Family Member 1

Alternate Names

ZNF201

Entrez Gene IDs

7545 (Human); 22771 (Mouse); 64618 (Rat)

Gene Symbol

ZIC1

UniProt

Q15915

Additional ZIC1 Products

Product Documents

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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