Human/Mouse/Rat Phospho-RSK1 (S380) Alexa Fluor® 700-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB79671N
Recombinant Monoclonal Antibody.
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunocytochemistry
Label
Alexa Fluor 700 (Excitation = 675-700 nm, Emission = 723 nm)
Antibody Source
Recombinant Monoclonal Rabbit IgG Clone # 1024A
Product Specifications
Immunogen
Phosphopeptide containing the human RSK1 S380 site
Accession # Q15418
Accession # Q15418
Specificity
Detects human, mouse, and rat RSK1 when phosphorylated at S380 in Western blots. Expected to detect RSK2, RSK3, and RSK4 phosphorylated at S386, S377, and S389, respectively, based on sequence homology.
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG
Applications
Application
Recommended Usage
Immunocytochemistry
Optimal dilution of this antibody should be experimentally determined.
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
Background: RSK1
RSK1 (ribosomal S6 kinase 1), gene name RPS6KA1 (ribosomal protein S6 kinase alpha1), also called p90RSK1 (90 kDa RSK1) or MAPKAPK 1a (MAPK-activated protein kinase 1a), is a widely expressed member of the RSK family of growth factor-regulated serine/threonine kinases. RSK proteins contain two non-identical kinase catalytic domains, and mediate activation of mitogen-activated kinase (MAPK) cascades and stimulation of cell proliferation and differentiation. Autophosphorylation on S380 allows binding of PDPK1, leading to further phosphorylation and full activation of RSK1 kinase activity. Human, mouse and rat RSK1 share 98% aa sequence identity, and are identical within the region of the peptide immunogen.
Long Name
Ribosomal Protein S6 Kinase I
Alternate Names
HU-1, MAPKAPL1A, RPS6KA1
Gene Symbol
RPS6KA1
UniProt
Additional RSK1 Products
Product Specific Notices
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
For research use only
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