Human/Mouse RASSF2 Alexa Fluor™ Plus 680-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # AF5639AFP680

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AF5639AFP680-100UG
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot, Immunocytochemistry

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Polyclonal Goat IgG

View all RASSF2 Antibodies »

Product Specifications

Specificity

Detects endogenous human and mouse RASSF2 in Western blots.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Background: RASSF2

RASSF2 (Ras association domain-containing protein 2; also RASSF2A) is a 34‑36 kDa member of the RASSF family of proteins. It is widely expressed, and serves as a tumor suppressor by interacting with K-Ras in a GTP-dependent manner, and activating caspase-3 and inducing apoptosis. Human RASSF2 is 326 amino acids (aa) in length. It contains a bipartite NLS (aa 151‑167), a Ras-association domain (aa 176‑264) and a SARAH domain (aa 272‑319) that mediates homo- and heterotypic interactions. Multiple isoforms exist. One shows an insertion of 13 aa after Lys213, a second shows a three aa substitution for aa 305‑326, and a third shows a 20 aa substitution for aa 1‑96, accompanied by a three aa substitution for aa 231‑326. RASSF2 is often found down regulated in lung-derived tumor cell lines.

Long Name

Ras Association [RalGDS/AF-6] Domain Family Member 2

Alternate Names

RASFADIN

Entrez Gene IDs

9770 (Human); 215653 (Mouse); 311437 (Rat)

Gene Symbol

RASSF2

UniProt

P50749

Additional RASSF2 Products

Product Documents

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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