Human/Mouse NCOA3 Alexa Fluor™ Plus 488-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF5076AFP488
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human, Mouse
Applications
Western Blot
Label
Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)
Antibody Source
Polyclonal Goat IgG
Product Specifications
Specificity
Detects endogenous human and mouse NCOA3 in Western blots.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications
Application
Recommended Usage
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Background: NCOA3
Nuclear Receptor Coactivator 3 (NCOA3) functions in the multisubunit coactivator complex. Multiple nuclear hormone receptors are able to bind to NCOA3 in a hormone dependent manor. NCOA3 contains intrinsic histone acetyltransferase activity, but is also able to recruit other histone aceytltransferases (CBP, PCAF) and methyltransferases (PRMT1, CARM1) to active promoters. NCOA3 null mice exhibit hematological, adiopogenesis, and endotoxic impairments. mRNA of NCOA3 is often amplified in several cancers including breast and ovarian.
Long Name
Nuclear Receptor Co-activator 3
Alternate Names
ACTR, AIB1, KAT13B, pCIP, RAC3, SRC-1, SRC-3, TRAM1
Gene Symbol
NCOA3
UniProt
Additional NCOA3 Products
Product Specific Notices
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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