Human/Mouse FGF-23 Antibody

Name: Human/Mouse FGF-23 Antibody
Brand: R&D Systems
SKU: MAB2629

R&D Systems, Inc. a Bio-Techne Brand

Catalog # MAB2629

Citations (4)

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Species Reactivity:	Human, Mouse
Immunogen:	Mouse myeloma cell line NS0-derived recombinant mouse FGF-23 Tyr25-Val251 (Arg179Gln) Accession # Q9EPC2
Applications:	Western Blot
Label:	Unconjugated
Source:	Monoclonal Rat IgG_2B Clone # 283511
Specificity:	Detects human and mouse FGF-23 in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) FGF acidic, rhFGF basic, rhFGF-3, -4, -5, -6, -7, -9, -10, -11, -12, -13, -16, -17, -18, -19, -20, -21, recombinant mouse (rm) FGF‑8b, rmFGF‑8c, or rmFGF-15.

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Applications for Human/Mouse FGF-23 Antibody

	Recommended Concentration	Sample
Western Blot	1 µg/mL	Recombinant Human FGF‑23 (Catalog # 2604-FG) Recombinant Mouse FGF‑23 (Catalog # 2629-FG)

Please Note: Optimal dilutions should be determined by each laboratory for each application.

Formulation, Preparation and Storage

Purification	Protein A or G purified from hybridoma culture supernatant
Reconstitution	Reconstitute at 0.5 mg/mL in sterile PBS. Reconstitution Buffer Available: Size / Price Qty Loading... RB01:
Formulation	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

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Background: FGF-23

FGF-23 is a secreted protein primarily expressed in the brain and thymus. Mutations in FGF-23 produced by osteomalacia tumors are linked to autosomal dominant hypophosphatemic rickets and several bone structure disorders.

Item	Value
Long Name	Fibroblast Growth Factor 23
Entrez Gene IDs	8074 (Human); 64654 (Mouse)
Alternate Names	ADHR, FGF-23, FGF23, HPDR2, HYPF, PHPTC, Tumor-derived hypophosphatemia-inducing factor, fibroblast growth factor 23, phosphatonin, tumor-derived hypophosphatemia inducing factor

Citations for Human/Mouse FGF-23 Antibody (4)

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Citations are publications that use Bio-Techne products. Selected citations for Human/Mouse FGF-23 Antibody include:

Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

N Quarto et al. (2018), Twist1-Haploinsufficiency Selectively Enhances the Osteoskeletal Capacity of Mesoderm-Derived Parietal Bone Through Downregulation of Fgf23 Front Physiol, 9(0):1426.
PMID: 30374308
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

ER Smith et al. (2017), FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts Sci Rep, 7(1):3345.
PMID: 28611350
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

Xiao Z et al. (2014), Osteocyte-specific deletion of Fgfr1 suppresses FGF23. PLoS ONE, 9(8):e104154.
PMID: 25089825
Species: Human
Sample Types: Plasma
Applications: Western Blot

Takaiwa M et al. (2010), Fibroblast growth factor 23 concentrations in healthy term infants during the early postpartum period. Bone, 47(2):256-62.
PMID: 20641162

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Product Documents for Human/Mouse FGF-23 Antibody

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Human/Mouse FGF-23 Antibody

R&D Systems, Inc. a Bio-Techne Brand

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