Human/Mouse CDC73 Alexa Fluor™ Plus 647-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # AF5508AFP647

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AF5508AFP647-100UG
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Alexa Fluor Plus 647 (Excitation = 658 nm, Emission = 675 nm)

Antibody Source

Polyclonal Goat IgG

View all CDC73 Antibodies »

Product Specifications

Specificity

Detects human and mouse CDC73 in Western blots.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Background: CDC73

CDC73 (also Parafibromin, HRPT2, and C1orf28) is a 60‑65 kDa member of the Cell Division Cycle family of proteins. It is found in adrenal, parathyroid and kidney, and serves as a regulator of Wnt signaling and a tumor suppressor by blocking c-myc expression. Human CDC73 is 531 amino acids (aa) in length. It contains multiple NLSs (aa 125‑139, 76‑92, and 393‑410) and a beta-catenin interaction sequence (aa 218‑263). There are at least two potential splice variants. One shows a five Lys substitution for aa 300‑531, while a second shows a 19 aa substitution for aa 298‑531. Full-length human and mouse CDC73 are completely (100%) identical in primary aa sequence.

Long Name

Cell Division Cycle 73

Alternate Names

HPT-JT, HRPT2, Parafibromin

Entrez Gene IDs

79577 (Human); 214498 (Mouse); 304832 (Rat)

Gene Symbol

CDC73

UniProt

Q6P1J9

Additional CDC73 Products

Product Documents

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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