Human Menin Alexa Fluor™ Plus 488-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF6005AFP488
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)
Antibody Source
Polyclonal Goat IgG
Product Specifications
Specificity
Detects human Menin in Western blots.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications for Human Menin Alexa Fluor™ Plus 488-conjugated Antibody
Application
Recommended Usage
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Background: Menin
Menin (Multiple endocrine neoplasia type I) is a 75‑78 kDa tumor‑suppressor protein that has no apparent structural relationship to any known protein family. It is ubiquitously expressed and interacts with other molecules, including NF kappaB, FANCD2 and ASK. Menin appears to block gene transcription, promote DNA repair, and inhibit cell proliferation. Human Menin is 615 amino acids (aa) in length. Consistent with its unique molecular taxonomy, it contains no definitive structural module(s). However, it is known to be phosphorylated on Ser399 and Thr599. There are a number of potential splice variants. Individually or in combination, there are deletions of aa 89‑95, 149‑153, 171‑173, 189‑223, and 423‑426. There is also a 50 aa substitution for aa 68‑615, a 66 aa substitution for aa 383‑615, and a two aa substitution for aa 507‑536. Over aa 555‑615, human and mouse Menin are completely identical in aa sequence.
Long Name
Multiple Endocrine Neoplasia I
Alternate Names
MEAI, MEN1
Gene Symbol
MEN1
UniProt
Additional Menin Products
Product Specific Notices for Human Menin Alexa Fluor™ Plus 488-conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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