Ly6/PLAUR domain containing 8 (LYPD8), is a GPI-linked protein with structural similarity to the urokinase-type plasminogen activator receptor (uPAR) (1). Mature human LYPD8 contains one uPAR/Ly6 domain and a Ser/Thr/Pro-rich (STP) region that may serve as a target for protease mediated shedding as has been shown for the related C4.4A/LYPD3 molecule (2, 3). Mature human LYPD8 shares 40% amino acid sequence identity with mouse and rat LYPD8.

References

Kong, H.K. and J.H. Park (2012) BMB Rep. 45:595.
Hansen, L.V. et al. (2004) Biochem. J. 380:845.
Esselens, C.W. et al. (2008) Biol. Chem. 389:1075.

Long Name

Ly6/PLAUR Domain-containing Protein 8

Entrez Gene IDs

646627 (Human); 70163 (Mouse); 691259 (Rat)

Gene Symbol

LYPD8

UniProt

Q6UX82

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Product Specific Notices for Human LYPD8 Alexa Fluor™ Plus 488-conjugated Antibody

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

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Human LYPD8 Alexa Fluor™ Plus 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB9087AFP488

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Applications for Human LYPD8 Alexa Fluor™ Plus 488-conjugated Antibody

CyTOF-ready

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Immunocytochemistry

Background: LYPD8