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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Alexa Fluor 594 (Excitation = 590 nm, Emission = 617 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 1060109

Product Specifications

Immunogen

Synthetic peptide sequence
Accession # Q16478

Specificity

Detects human KA2/GRIK5 in direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human KA2/GRIK5 Alexa Fluor® 594-conjugated Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: KA2/GRIK5

GRIK5 (Glutamate receptor, ionotropic kainate 5) is a receptor for glutamate and is one of the 5 types of kainate receptor subunits.  L-Glutamate acts as an excitatory neurotransmitter at many synapses in the CNS. The GRIK5 protein forms functional heteromic kainate-preferring ionic channels with the subunits encoded by related gene family members.  Kainate receptors have both presynaptic and postsynaptic actions and a limited distribution in the brain. Kainate receptors have been shown to have connections with several neurological diseases and conditions.  There is linkage to schizophrenia, depression, autism, Huntington's, bipolar disorder, and epilepsy among others.  KA2 is relatively abundant in all areas of the brain, most notably in dentate gyrus, pyramidal neurons of CA3, cerebellar granule cells, as well as being present in superficial and deep laminae of the neocortex.

Long Name

Glutamate Receptor KA2

Alternate Names

EAA2, GluK5, GRIK2, GRIK5

Entrez Gene IDs

2901 (Human); 14809 (Mouse); 24407 (Rat)

Gene Symbol

GRIK5

UniProt

Additional KA2/GRIK5 Products

Product Documents

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human KA2/GRIK5 Alexa Fluor® 594-conjugated Antibody


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

For research use only

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