Human Integrin alpha1/CD49a Alexa Fluor™ Plus 555-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB56761AFP555
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Flow Cytometry
Label
Alexa Fluor Plus 555 (Excitation = 558 nm, Emission = 572 nm)
Antibody Source
Recombinant Monoclonal Rabbit IgG Clone # 1090A
Product Specifications
Immunogen
Chinese hamster ovary cell line CHO derived recombinant human Integrin alpha1 beta1
Met1-Pro1141 (Integrin alpha1) & Gln21-Asp728 (Integrin beta1)
Accession # P56199
Met1-Pro1141 (Integrin alpha1) & Gln21-Asp728 (Integrin beta1)
Accession # P56199
Specificity
Detects Integrin alpha1/CD49a in direct ELISAs.
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG
Activity
None
Applications
Application
Recommended Usage
Flow Cytometry
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
BulkLotPrefix assignment required for Storage Info
Background: Integrin alpha 1/CD49a
Integrin alpha1 (also VLA-1, CD49a and Laminin and Collagen Receptor) is a 190-210 kDa member of the integrin alpha chain family of molecules. It is found on smooth muscle cells, osteoblasts, adipocytes and intestinal epithelium. Integrin alpha1 forms a noncovalent heterodimer with Integrin beta1, and serves as a divalent-cation dependent receptor for collagen types I, IV, VI, XIII and XVI. It also binds the diarrhea-associated NSP4 enterotoxin of rotavirus. Mature human Integrin alpha1 is a 1151 amino acid (aa) type I transmembrane glycoprotein that contains a 1113 aa extracellular domain (ECD) and a 15 aa cytoplasmic tail. The ECD contains one vWFA/I-domain (aa 147-360) that binds collagen, plus multiple divalent cation binding sites. Potential splice variants exist that show a two and four aa substitution for aa 765-1179. Over aa 29-1141 (the ECD), human Integrin alpha1 shares 88% aa identity with mouse Integrin alpha1.
Alternate Names
CD49a, ITGA1, VLA-1
Gene Symbol
ITGA1
UniProt
Additional Integrin alpha 1/CD49a Products
Product Specific Notices
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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