Insulin Growth Factor-like Family Receptor 1 (IGFLR1) is a 355 amino acid (aa) type 1a transmembrane protein that was identified in a screen for binding partners of human IGFL-1 (1). Mature human IGFLR1 consists of an extracellular domain (ECD) with two putative cysteine-rich domains (CRDs), a transmembrane region, and a cytoplasmic domain (1). Its structure has similarities to TNF receptor family members (1). Over the first 163 aa, human IGFLR1 shares 61% and 59% aa sequence identity with mouse and rat IGFLR1, respectively. In mice, IGFLR1 is expressed primarily on T cells and, similar to the human proteins, mouse IGFLR1 binds the mouse IGFL protein (1). Human IGFL-1 expression is enhanced by TNF-alpha treatment and was shown to be up-regulated in human psoriatic skin samples, suggesting that IGFLR1 may have a role during skin inflammation (1).

References

Lobito, A.A. et al. (2011) J. Biol. Chem. 286:18969.

Long Name

IGF-like Family Receptor 1

Alternate Names

TMEM149, U2AF1L4

Entrez Gene IDs

79713 (Human); 101883 (Mouse); 499126 (Rat)

Gene Symbol

IGFLR1

UniProt

Q9H665

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Product Specific Notices for Human IGFLR1 Alexa Fluor™ Plus 594-conjugated Antibody

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

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Human IGFLR1 Alexa Fluor™ Plus 594-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB8296AFP594

Key Product Details

Species Reactivity

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Antibody Source

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Product Specifications

Immunogen

Specificity

Clonality

Host

Isotype

Applications for Human IGFLR1 Alexa Fluor™ Plus 594-conjugated Antibody

Blockade of Receptor-ligand Interaction

CyTOF-ready

Flow Cytometry

Formulation, Preparation, and Storage

Formulation

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Stability & Storage

Background: IGFLR1