Human DGAT2 Alexa Fluor® 647-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF7256R
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Immunohistochemistry, Immunocytochemistry
Label
Alexa Fluor 647 (Excitation = 650 nm, Emission = 668 nm)
Antibody Source
Polyclonal Sheep IgG
Product Specifications
Immunogen
E. coli-derived recombinant human DGAT2
Arg268-Phe377
Accession # Q96PD7
Arg268-Phe377
Accession # Q96PD7
Specificity
Detects human DGAT2 in direct ELISAs. In direct ELISAs, approximately 7% cross-reactivity with recombinant human DGAT2-L6 is observed.
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Applications for Human DGAT2 Alexa Fluor® 647-conjugated Antibody
Application
Recommended Usage
Immunocytochemistry
Optimal dilution of this antibody should be experimentally determined.
Immunohistochemistry
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Formulation
Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
Background: DGAT2
DGAT2 (Diacylglycerol O-acyltransferase 2; also DGAT2 alpha) is a 45-50 kDa, insulin-regulated member of the DGAT2 family of enzymes. Although DGAT1 also exists, it is related to DGAT2 only by function; DGAT1 and DGAT2 are members of structurally unrelated gene families. DGAT2 catalyzes the formation of triglyceride (TG) from sn-1, 2-DG and a variety of acyl-CoAs. It is found in sebaceous gland cells, adipocytes, and hepatocytes, and appears to synthesize TGs for incorporation into VLDL particles. Human DGAT2 is a 388 amino acid (aa) multipass ER protein. It contains a 69 aa N-terminal cytoplasmic region, a short luminal sequence (aa 89-92) and a long C-terminal cytoplasmic domain that contains acyl transferase activity (aa 113-388). DGAT2 does homomultimerize, forming 680 kDa complexes. There is one splice variant that contains a deletion of aa 41-83. Over aa 268-377, human DGAT2 shares 95% aa sequence identity with mouse DGAT2.
Long Name
Diacylglycerol O-Acyltransferase 2
Alternate Names
diacylglycerol O-acyltransferase 2, diacylglycerol O-acyltransferase homolog 2, diacylglycerol O-acyltransferase homolog 2 (mouse), diacylglycerol O-acyltransferase-like protein 2, Diglyceride acyltransferase 2, DKFZp686A15125, EC 2.3.1, EC 2.3.1.20, GS1999FULL
Gene Symbol
DGAT2
UniProt
Additional DGAT2 Products
Product Specific Notices for Human DGAT2 Alexa Fluor® 647-conjugated Antibody
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
For research use only
Loading...
Loading...
Loading...