Human CRELD2  alpha Isoform Alexa Fluor™ Plus 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # AF3555AFP488

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AF3555AFP488-100UG
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Polyclonal Goat IgG

View all CRELD2 Antibodies »

Product Specifications

Specificity

Detects human CRELD2 alpha isoform in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 30% cross‑reactivity with recombinant mouse (rm) CRELD2 is observed and less than 1% cross-reactivity with recombinant human CRELD1 and rmCRELD1 is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Background: CRELD2

CRELD2 is an ubiquitously expressed protein that is a second member of the CRELD family of matricellular proteins. Human CRELD2 alpha isoform is synthesized as a 353 amino acid residue precursor protein with a signal peptide, a highly conserved domain rich in glutamic acid and tryptophan (WE), and EGF-like repeats. Multiple isoforms, including the beta isoform with a 27 aa substitution for the C-terminal 96 residues of the alpha isoform, and another isoform with a 32 residue deletion between residues 258 and 289, have been reported. Human CRELD2 has been shown to interact with the alpha4 subunit of the nicotinic acetylcholine receptor and function as a specific regulator of receptor expression. Human CRELD2 shares 76% and 77% amino acid sequence homology with mouse and rat CRELD 2, respectively.

Long Name

Cysteine-rich Protein With EGF-like Domains 2

Alternate Names

cysteine-rich with EGF-like domain protein 2, cysteine-rich with EGF-like domains 2, DKFZp667O055, MGC11256

Entrez Gene IDs

79174 (Human); 76737 (Mouse)

Gene Symbol

CRELD2

UniProt

AAH50675

Additional CRELD2 Products

Product Documents

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Certificate of Analysis

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Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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