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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Immunoprecipitation

Label

Alexa Fluor 488 (Excitation = 488 nm, Emission = 515-545 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 390513

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Complement Factor H-related 5/CFHR5
Glu19-Glu569
Accession # Q9BXR6

Specificity

Detects human Complement Factor H-related 5/CFHR5 in direct ELISAs and Western blots.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications

Application
Recommended Usage

Immunoprecipitation

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Complement Factor H-related 5/CFHR5

Complement factor H-related protein 5 (FHR-5 or CFHR5) is a 65 kDa member of the factor H-related protein family.  It is secreted by the liver and circulates either free or bound to HDL.  It is unique among FHR proteins in that it associates with complexes that arise from complement activation.  It promotes C3b cleavage and blocks C3 convertase activity.  Human CFHR5 is 551 amino acids (aa) in length.  It contains nine, 60 aa SUSHI-, or short consensus repeats, plus 18 intrachain disulfide bonds. SUSHI repeats 5-7 (aa 267-444) reportedly mediate CFHR5 binding to CRP and heparin.  The complement interaction site(s) is unknown.  Human CFHR5 shares 64% aa sequence identity with canine CFHR5.

Alternate Names

CFHL5, CFHR5, Complement Factor Hrelated 5, FHR5

Entrez Gene IDs

81494 (Human)

Gene Symbol

CFHR5

UniProt

Additional Complement Factor H-related 5/CFHR5 Products

Product Documents

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

For research use only

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