Detects human Complement Factor H-related 1/CFHR1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human (rh) CFHR2 or rhCFHR5 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2B

Applications for Human Complement Factor H-related 1/CFHR1 Antibody

Application

Recommended Usage

Immunoprecipitation

25 µg/mL
Sample: Conditioned cell culture medium spiked with Recombinant Human Complement Factor H‑related 1/CFHR1, see our available Western blot detection antibodies

Western Blot

1 µg/mL
Sample: Recombinant Human Complement Factor H-related 1/CFHR1 under non-reducing conditions

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Complement Factor H-related 1/CFHR1

Complement factor H-related protein 1 (CFHR1) is a 43 kDa, secreted member of the factor H family of glycoproteins. It is produced by hepatocytes and circulates as two differentially glycosylated isoforms (37 kDa and 43 kDa). Mature human CFHR1 is 312 aa in length. It contains five approximately 60 aa SCRs (short consensus repeats/CCPs/SUSHI repeats) that basically constitute the entire molecule. CFHR1 may play a role in lipoprotein complexes that bind LPS to neutrophils. There is no reported rodent counterpart to CFHR1. Over aa 19‑143 of the CFHR1 precursor, human CFHR2 and CFHR5 show 98% and 86% aa identity, respectively.

Alternate Names

BTA, CFHR1, Complement Factor Hrelated 1, FHR1

Entrez Gene IDs

3078 (Human)

Gene Symbol

CFHR1

UniProt

Q03591

Additional Complement Factor H-related 1/CFHR1 Products

Product Documents for Human Complement Factor H-related 1/CFHR1 Antibody

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for Human Complement Factor H-related 1/CFHR1 Antibody

For research use only

Citations
Reviews

Human Complement Factor H-related 1/CFHR1 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB4247

Key Product Details

Species Reactivity

Validated:

Cited:

Applications