Carcinoembryonic Antigen-related Cell Adhesion Molecule 16 (CEACAM-16), or CEAL2, is part of the CEA protein family consisting of CEACAMs and the pregnancy‑specific glycoproteins (PSGs). Both CEACAM and PSG molecules have been identified in humans and belong to the much larger glycosylphosphatidylinositol (GPI)-linked immunoglobulin (Ig) superfamily (1, 2). Unique to the CEA family, CEACAM-16 is a secreted molecule lacking a recognizable transmembrane domain or GPI anchor (3). Mature human CEACAM-16 is 405 amino acids (aa), containing 2 IgC2-like domains and 2 IgV-like domains. CEACAM-16 is one of only five conserved CEACAMs among mice, rats, and humans (2). Mature human CEACAM-16 shares 90% and 89% aa identity with mouse and rat CEACAM‑16, respectively. Originally discovered as a biomarker for colorectal cancer (4), CEACAMs have now been associated with numerous intracellular signaling processes including cell adhesion, cell growth, recognition and differentiation, angiogenesis, and apoptosis (5-7). CEACAM-16 is specifically expressed in the inner ear and has been shown to play a critical role in hearing. CEACAM-16 has been identified as a binding partner for alpha tectorin and specific mutations in CEACAM-16 have been linked to autosomal dominant nonsyndromic deafness (ADNSHL) (3, 8).

References

Beauchemin, N. et al. (1999) Exp. Cell Res. 252:243.
Zebhauser R. et al. (2005) Genomics 86:566.
Zheng, J. et al. (2011) PNAS. 108(10):4218.
Gold P. and Freedman S.O. (1965) J Exp Med 122:467.
Obrink, B. (1997) Curr Opin Cell Biol 9:616.
Horst, A.K. and Wagener, C. (2004) Handb Exp Pharmacol 283.
Kuespert K et al. (2006) Curr Opin Cell Biol. 18(5):565.
Wang, H. et al. (2015) J Hum Genet. 60(3):119.

Long Name

Carcinoembryonic Antigen-related Cell Adhesion Molecule 16

Alternate Names

CEAL2, DFNA4B

Entrez Gene IDs

388551 (Human); 330483 (Mouse); 292700 (Rat)

Gene Symbol

CEACAM16

UniProt

Q2WEN9

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This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

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Human CEACAM-16 Alexa Fluor™ Plus 647-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB9885AFP647

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Background: CEACAM-16