Human CD81 Alexa Fluor™ Plus 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB46152AFP488

Catalog #
Availability
Size / Price
Qty
FAB46152AFP488-100UG
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 2664C

View all CD81 Antibodies »

Product Specifications

Specificity

Detects human CD81 in Elisas.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Applications for Human CD81 Alexa Fluor™ Plus 488-conjugated Antibody

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Background: CD81

CD81, also known as TAPA-1 and Tetraspanin-28, is an approximately 25 kDa palmitoylated component of plasma membrane lipid rafts (1). It contains four transmembrane segments, two extracellular loops of 30 and 90 amino acids (aa), and three short cytoplasmic regions (2, 3). Within the large extracellular loop, human CD81 shares 90% and 84% aa sequence identity with mouse and rat CD81, respectively. CD81 associates with a wide range of membrane proteins including CD151, TfR2, LDL R, PCSK9, Glypican 3, IFITM1, IGSF8/CD316, FPRP, and complexes of CD19-CD21 (4-11). It is required for the development of CD4+CD8+ DP thymocytes (12) and hepatocyte infection by Plasmodium sporozoites (13). It also supports B cell receptor signaling (11), Hepcidin expression (5), monocyte and B cell tethering to the vascular endothelium (14), and the immunosuppressive function of Treg and MDSC (15). CD81 additionally functions as a receptor for the E2 glycoprotein of hepatitis C virus (16). The CD81-E2 interaction inhibits NK cell cytolytic activity, provides a co-stimulatory signal to T cells, and inhibits the maturation of plasmacytoid dendritic cells (17-19).

References

  1. Charrin, S. et al. (2014) J. Cell Sci. 127:3641.
  2. Oren, R. et al. (1990) Mol. Cell. Biol. 10:4007.
  3. Levy, S. et al. (1991) J. Biol. Chem. 266:14597.
  4. Zhu, Y.-Z. et al. (2012) Virology 429:112.
  5. Chen, J. and C.A. Enns (2015) J. Biol. Chem. 290:7841.
  6. Le, Q.-T. et al. (2015) J. Biol. Chem. 290:23385.
  7. Takahashi, S. et al. (1990) J. Immunol. 145:2207.
  8. Stipp, C.S. et al. (2001) J. Biol. Chem. 276:40545.
  9. Stipp, C.S. et al. (2001) J. Biol. Chem. 276:4853.
  10. Liu, B. et al. (2009) Am. J. Pathol. 175:717.
  11. Cherukuri, A. et al. (2004) J. Immunol. 279:31973.
  12. Boismenu, R. et al. (1996) Science 271:198.
  13. Silvie, O. et al. (2003) Nat. Med. 9:93.
  14. Feigelson, S.W. et al. (2003) J. Biol. Chem. 278:51203.
  15. Vences-Catalan, F. et al. (2015) Cancer Res. 75:4517.
  16. Pileri, P. et al. (1998) Science 282:938.
  17. Crotta, S. et al. (2002) J. Exp. Med. 195:35.
  18. Tseng, C.-T. and G.R. Klimpel (2002) J. Exp. Med. 195:43.
  19. Tu, Z. et al. (2013) Cell. Immunol. 284:98.

Alternate Names

CD81, TAPA-1, TSPAN28

Entrez Gene IDs

975 (Human); 12520 (Mouse); 25621 (Rat)

Gene Symbol

CD81

UniProt

P60033

Additional CD81 Products

Product Documents

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human CD81 Alexa Fluor™ Plus 488-conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.