Brain angiogenesis inhibitor 2 (BAI2), along with BAI1 and BAI3, form a subfamily of brain specific adhesion GPCRs. They are large, glycosylated molecules, approximately 180-220 kDa, and play a role in neuronal synapse formation and maintenance. Mature human BAI2 consists of a 903 amino acid (aa) N-terminal extracellular domain (ECD) containing four TSP1 domains, a hormone binding domain (HBD), a GAIN domain and a GPS protease sensitive linker, followed by a region with seven transmembrane segments and a 410 aa C-terminal cytoplasmic domain (1). Within the N-terminal ECD, human BAI2 shares 96% aa sequence identity with both mouse and rat BAI2. BAI2 is expressed primarily in neurons and astrocytes of the hippocampus and cerebral cortex in the brain (2, 3). To become functional, BAI2 might require activation by cleavage at the GPS domain (4). BAI family members are known to bind the C1q-like complement (C1qL) family via thrombospondin type 1 repeats (TSRs) which are conserved between BAI members (5). BAI2 has been shown to suppress expression of VEGF leading to increased neurogenesis in the dentate gyrus of the hippocampus (6).

References

Duman, J.G. et al. (2016) Neural Plast. 2016:8301737.
Shiratsuchi, T. et al. (1997) Cytogenet. Cell Genet. 79:103.
Kee, H.J. et al. (2002) J. Cereb. Blood Flow Metab. 22:1054.
Daisuke, O. et al. (2010) J. Recept Signal Transduct Res 30:143.
Bolliger, M.F. et al. (2011) Proc. Natl. Acad. Sci. USA 108:2534.
Jeong, B.C. et al. (2016) FEBS Lett 580:669.

Long Name

Brain-specific Angiogenesis Inhibitor 2

Alternate Names

brain-specific angiogenesis inhibitor 2, Brain-specific angiongenesis inhibitor-2

Entrez Gene IDs

576 (Human); 230775 (Mouse); 313058 (Rat)

Gene Symbol

ADGRB2

UniProt

O60241-3

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Product Specific Notices for Human BAI2 Alexa Fluor™ Plus 488-conjugated Antibody

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

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Human BAI2 Alexa Fluor™ Plus 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB9338AFP488

Key Product Details

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Product Specifications

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Applications for Human BAI2 Alexa Fluor™ Plus 488-conjugated Antibody

CyTOF-ready

Flow Cytometry

Western Blot

Background: BAI2