Human ADAM19 Alexa Fluor™ Plus 680-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF5050AFP680
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot, Immunoprecipitation
Label
Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)
Antibody Source
Polyclonal Sheep IgG
Product Specifications
Specificity
Detects human ADAM19 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 25% cross-reactivity with recombinant mouse ADAM19 is observed, and less than 5% cross-reactivity with recombinant human (rh) ADAM8, rhADAM12, and rhADAM33 is observed.
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Applications for Human ADAM19 Alexa Fluor™ Plus 680-conjugated Antibody
Application
Recommended Usage
Immunoprecipitation
Optimal dilution of this antibody should be experimentally determined.
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Background: ADAM19
ADAM19 (a disintegrin and metalloprotease 19; also MADDAM and Meltrin-beta) is a 95‑100 kDa member of the M12B peptidase family of enzymes. It is expressed on multiple cell types including monocytes, fibroblasts, osteoblasts and dendritic cells. The human ADAM19 proenzyme is a 931 amino acid (aa) type I transmembrane protein. It contains a 178 aa cleavable proregion (aa 26‑203) and a 497 aa extracellular domain (ECD) (aa 204‑702). The ECD contains a metalloprotease domain (aa 211‑409), a disintegrin region (aa 417‑503) and a Cys-rich domain (aa 504‑650). The ECD circulates in plasma bound to 700 kDa alpha2-Macroglobulin. One splice variant shows an alternate start site at Met71, while two isoforms show variations after Lys902. Over aa 205‑702, human ADAM19 is 87% aa identical to mouse ADAM19.
Long Name
A Disintegrin and Metalloprotease-like Domain 19
Alternate Names
Meltrin beta
Gene Symbol
ADAM19
UniProt
Additional ADAM19 Products
Product Specific Notices for Human ADAM19 Alexa Fluor™ Plus 680-conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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