HPV18 E6 Antibody (BF7) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB100-2769

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Virus

Applications

Western Blot, ELISA, Radioimmunoassay

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # BF7

Format

BSA Free

Concentration

1 mg/ml

View all HPV18 E6 Antibodies »

Product Specifications

Immunogen

Gel-purified HPV18 E6-beta galactosidase fusion protein.

Reactivity Notes

Herpes simplex virus (HSV)

Localization

Nuclear

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

16.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Applications for HPV18 E6 Antibody (BF7) - BSA Free

Application
Recommended Usage

ELISA

1:100 - 1:2000

Radioimmunoassay

1:100 - 1:2000

Western Blot

1:100 - 1:2000
Application Notes
Positive control(s): HPV infected tissue.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HPV18 E6

Human Papilloma virus (HPV) is responsible for the development of type and tissue specific papilloma in the oral cavity and in the larynx. In the skin papilloma virus can cause different types of warts and in the ano-genital region it is associated with condyloma or carcinoma. HPV types 1, 6 and 11 usually are associated with benign transformations of the tissues, while e.g. HPV types 16, 18 and 31 seem to be responsible for the development of some carcinoma like cervical carcinoma. The role of HPV in non-melanoic tumours of the skin is under discussion. Protein E6 is a Transcriptional transactivator, binding double stranded DNA. It has transforming activity inactivating, with E6-AP ubiquitin-protein ligase, the human TP53/p53 tumor suppressor protein by targeting it for degradation. Clinical relevance: Detection of HPV in cervical smears and biopsies. Uses: Analysis of E6 expression in cell transformation studies.

Alternate Names

E6, HpV18gp1, Human papillomavirus type 18 E6, Protein E6

Additional HPV18 E6 Products

Product Documents for HPV18 E6 Antibody (BF7) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for HPV18 E6 Antibody (BF7) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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