HMG-CoA Reductase/HMGCR Antibody (CL0259)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-52097

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-52097-25ul
NBP3-52097-100ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Mouse IgG2A Clone # CL0259

Concentration

1 mg/ml

View all HMG-CoA Reductase/HMGCR Antibodies »

Product Specifications

Immunogen

This antibody was developed using a recombinant protein derived from P04035, with the exact immunogen sequence remaining proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for HMG-CoA Reductase/HMGCR Antibody (CL0259)

HMG-CoA Reductase/HMGCR Antibody (CL0259) Immunohistochemistry: HMG-CoA Reductase/HMGCR Antibody (CL0259) [NBP3-52097]

Immunohistochemistry: HMG-CoA Reductase/HMGCR Antibody (CL0259) [NBP3-52097]

Staining of human skeletal muscle shows no positivity in myocytes as expected.
HMG-CoA Reductase/HMGCR Antibody (CL0259) Immunohistochemistry: HMG-CoA Reductase/HMGCR Antibody (CL0259) [NBP3-52097]

Immunohistochemistry: HMG-CoA Reductase/HMGCR Antibody (CL0259) [NBP3-52097]

Analysis in human liver and skeletal muscle tissues. Corresponding HMG-CoA Reductase/HMGCR RNA-seq data are presented for the same tissues.
HMG-CoA Reductase/HMGCR Antibody (CL0259) Immunohistochemistry: HMG-CoA Reductase/HMGCR Antibody (CL0259) [NBP3-52097]

Immunohistochemistry: HMG-CoA Reductase/HMGCR Antibody (CL0259) [NBP3-52097]

Staining of human breast cancer shows moderate cytoplasmic positivity in tumor cells.
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Applications for HMG-CoA Reductase/HMGCR Antibody (CL0259)

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50

Western Blot

1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HMG-CoA Reductase/HMGCR

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Long Name

3-Hydroxy-3-Methylglutaryl-CoA Reductase

Alternate Names

HMGCR, Hydroxymethylglutaryl-CoA Reductase, LDLCQ3

Gene Symbol

HMGCR

Additional HMG-CoA Reductase/HMGCR Products

Product Documents for HMG-CoA Reductase/HMGCR Antibody (CL0259)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for HMG-CoA Reductase/HMGCR Antibody (CL0259)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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