GSK-3 beta Antibody (23GB1250)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51966

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NBP3-51966-100ul
NBP3-51966-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 23GB1250

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GSK-3 beta Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human GSK-3 beta (Uniprot: P49841)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GSK-3 beta Antibody (23GB1250)

GSK-3 beta Antibody (23GB1250)

Immunocytochemistry/ Immunofluorescence: GSK-3 beta Antibody (23GB1250)[NBP3-51966] -

Immunocytochemical staining of HT-1080 cells with GSK-3 beta antibody (1:1,000). Nuclei were stained blue with DAPI; GSK-3 beta was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 um.
GSK-3 beta Antibody (23GB1250)

Flow Cytometry: GSK-3 beta Antibody (23GB1250)[NBP3-51966] -

Validation of GSK-3 beta knockdown using flow cytometry. Wild-type(WT, Blue) and knockdown(KD, Green) HeLa cells were stained with GSK-3 beta antibody (1:2,000) and analyzed using BD flow cytometer.
GSK-3 beta Antibody (23GB1250)

Flow Cytometry: GSK-3 beta Antibody (23GB1250)[NBP3-51966] -

Flow cytometric analysis of GSK-3 betaexpression in HepG2 cells using GSK-3 beta antibody (1:2,000). Green, isotype control; red, Glycogen synthase kinase 3 beta.

Applications for GSK-3 beta Antibody (23GB1250)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GSK-3 beta

Glycogen synthase kinase 3beta (GSK-3 beta) is a Serine/Threonine protein kinas involved in the insulin and wingless pathways (1-2). Originally identified as a regulator of glycogen synthase, it has been shown to regulate a diverse array of cellular functions. GSK-3 beta activity is down regulated by phosphorylation on Serine 9 by PKB, or activated by phosphorylation on Tyrosine 216. Once activated, the protein can phosphorylate p53, c-jun, heat shock factor-1 and cyclin D1 (3-4). It is also known to phosphorylate Tau in Allzheimer's disease. Additionally, increased GSK-3 beta protein levels are found in Alzheimer's disease brains.

Long Name

Glycogen Synthase Kinase 3 beta

Alternate Names

GSK3 beta, GSK3B

Gene Symbol

GSK3B

Additional GSK-3 beta Products

Product Documents for GSK-3 beta Antibody (23GB1250)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for GSK-3 beta Antibody (23GB1250)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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