Glycogen synthases kinase 3 alpha (GSK3-alpha) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-alpha activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-alpha by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-alpha activitiy has been linked to a pathogenic mechanism in Alzheimer's disease (4).

Long Name

Glycogen Synthase Kinase 3 alpha

Alternate Names

GSK3 alpha, GSK3A

Gene Symbol

GSK3A

Additional GSK-3 alpha Products

Product Documents for GSK-3 alpha [p Ser21] Antibody [PE]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for GSK-3 alpha [p Ser21] Antibody [PE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

GSK-3 alpha [p Ser21] Antibody [PE]

Novus Biologicals, part of Bio-Techne | Catalog # AF4125P

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

Concentration

View all GSK-3 alpha Antibodies »

Product Specifications

Immunogen

Modification

Specificity

Clonality

Host

Isotype

Applications for GSK-3 alpha [p Ser21] Antibody [PE]

Immunohistochemistry

Western Blot

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: GSK-3 alpha