Glucagon R/GCGR Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS4256

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NLS4256
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Key Product Details

Species Reactivity

Validated:

Human, Rat, Monkey, Primate

Cited:

Human, Rat

Predicted:

Equine (94%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all Glucagon R/GCGR Antibodies »

Product Specifications

Immunogen

Synthetic 18 amino acid peptide from N-terminal extracellular domain of human Glucagon R/GCGR.

Epitope

N-Terminus extracellular domain

Reactivity Notes

Human, Rat reactivity reported in (PMID:23685839). Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Mouse (89%), Hamster (89%), Bovine (89%), Canine (89%).

Localization

Plasma membrane

Specificity

Human Glucagon R/GCGR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for Glucagon R/GCGR Antibody - BSA Free

Immunohistochemistry-Paraffin: Glucagon R/GCGR Antibody - BSA Free [NLS4256]

Immunohistochemistry-Paraffin: Glucagon R/GCGR Antibody - BSA Free [NLS4256]

Immunohistochemistry-Paraffin: Glucagon R/GCGR Antibody [NLS4256] - Analysis of anti-Glucagon Receptor antibody with human liver.

Applications for Glucagon R/GCGR Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

13 ug/ml
Application Notes
Use in WB reported in scientific literature (PMID: 23685839)..

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: Glucagon R/GCGR

The Glucagon Receptor mediates the effects of glucagon in controlling glucose metabolism by initiating a cascade of events that regulate the amount of glucose released from the liver into the bloodstream. Glucagon generally functions as a counterregulatory hormone, opposing the actions of insulin, in maintaining the levels of blood glucose, particularly in patients with hypoglycemia. In patients with diabetes, excess glucagon secretion plays a primary role in the metabolic perturbations associated with diabetes, such as hyperglycemia. Glucagon knockout mice exhibit reduced glood glucose levels, improved glucose tolerance, elevated blood glucagon levels, and normal insulin levels. Despite a total absence of glucagon receptors, these animals maintained near-normal glycemia and normal lipidemia, in the presence of circulating glucagon concentrations that were elevated by two orders of magnitude. A missense mutation (Gly40Ser) in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. The glucagon receptor has been reported to be expressed in liver and adipose, but not in adrenal medulla. ESTs have been isolated from liver/spleen and kidney libraries.

Long Name

Glucagon Receptor

Alternate Names

GCGR, GGR, GLR, GlucagonR

Entrez Gene IDs

2642 (Human)

Gene Symbol

GCGR

UniProt

P47871

Additional Glucagon R/GCGR Products

Product Documents for Glucagon R/GCGR Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Glucagon R/GCGR Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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