GAP-43 Antibody (CL10847) - BSA Free
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21181
![Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] -](https://resources.bio-techne.com/images/products/nbp3-21181_mouse-gap-43-mab-cl10847-45202315485217.jpg "Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] -")
![Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] -](https://resources.bio-techne.com/images/products/nbp3-21181_mouse-gap-43-mab-cl10847-45202315493227.jpg "Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] -")
![Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] -](https://resources.bio-techne.com/images/products/nbp3-21181_mouse-gap-43-mab-cl10847-45202315463320.jpg "Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] -")
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Validated by
Orthogonal Validation
Species Reactivity
Human
Applications
Immunohistochemistry, Immunohistochemistry-Paraffin
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2B Clone # CL10847
Format
BSA Free
Concentration
1 mg/ml
Product Specifications
Immunogen
This antibody was developed using a synthetic peptide derived from P17677, with the exact immunogen sequence remaining proprietary.
Reactivity Notes
Mouse, Rat (85%).
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2B
Scientific Data Images for GAP-43 Antibody (CL10847) - BSA Free
![Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] -](https://resources.bio-techne.com/images/products/nbp3-21181_mouse-gap-43-mab-cl10847-4520231553432.jpg "Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] -")
Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] -
Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] - Staining of human rectum shows strong positivity in peripheral ganglia and nerves.![Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] -](https://resources.bio-techne.com/images/products/nbp3-21181_mouse-gap-43-mab-cl10847-45202315522617.jpg "Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] -")
Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] -
Immunohistochemistry-Paraffin: GAP-43 Antibody [NBP3-21181] - Staining of human skeletal muscle shows no positivity in myocytes as expected.Applications for GAP-43 Antibody (CL10847) - BSA Free
Application
Recommended Usage
Immunohistochemistry
1:500 - 1:1000
Immunohistochemistry-Paraffin
1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Formulation, Preparation, and Storage
Purification
Protein A purified
Formulation
PBS (pH 7.2) and 40% Glycerol
Format
BSA Free
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Background: GAP-43
Heterozygous GAP3 knockout mice with GAP-43 levels reduced by one-half display significant memory impairments in cued conditioning, or on tests of nociceptive or auditory perception. Differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. Therefore, the neuronal precursor pool in the cerebellum fails to grow resulting in a cerebellum that is significantly smaller than normal. Total GAP-43 deletion is lethal within days of birth, demonstrating that GAP-43 is critical for the proper development of the mammalian CNS.
Long Name
Growth Associated Protein 43
Alternate Names
B-50, Basp2, GAP43, Neuromodulin
Gene Symbol
GAP43
Additional GAP-43 Products
Product Documents for GAP-43 Antibody (CL10847) - BSA Free
Product Specific Notices for GAP-43 Antibody (CL10847) - BSA Free
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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