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FOXL2 Antibody

Catalog # NBP2-22473 | Novus Biologicals a Bio-Techne Brand
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NBP2-22473
NBP2-22473-0.025mg

Key Product Details

Species Reactivity

Human, Mouse, Hamster

Applications

Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

Product Summary for FOXL2 Antibody

Immunogen

Synthetic Peptide corresponding to residues M(1) M A S Y P E P E D T A G T(14) of mouse FoxL2.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID:32814714). Human reactivity reported in scientific literature (PMID: 19797124). .

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for FOXL2 Antibody

Immunocytochemistry/Immunofluorescence: FOXL2 Antibody [NBP2-22473] - Staining in KK1 granulosa cells.
Immunohistochemistry-Paraffin: FOXL2 Antibody [NBP2-22473] - Staining of FoxL2 in murine prenatal follicle.

Applications for FOXL2 Antibody

Application
Recommended Usage

Chromatin Immunoprecipitation (ChIP)

1-3 ug/ 10^6 cells

Immunocytochemistry/ Immunofluorescence

2 ug/ml

Immunohistochemistry

0.2 ug/ml

Immunohistochemistry-Paraffin

0.2 ug/ml

Western Blot

0.2 ug/ml
Application Notes
Use in Flow Cytometry reported in scientific literature (PMID:32814714)WB: Detects an approx. 39 Knockdown Validateda protein representing FozL2 in CHO whole cell lysate.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Published Applications

Read 1 publication using NBP2-22473 in the following applications:

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: FOXL2

There are 2 forms of the blepharophimosis/ptosis/epicanthus inversus syndrome. In one form, called type I, eyelid abnormalities are associated with ovarian failure. In the second type, called type II, only the eyelid defects are found. Both types map to 3q23. Crisponi et al. (2001) refined the physical mapping of the BPES critical region and positionally cloned a novel, putative winged helix/forkhead transcription factor gene, FOXL2, in which they found mutations to produce truncated proteins in type I families and larger proteins in type II. Consistent with an involvement in those tissues, FOXL2 was selectively expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles; in adult humans, it appeared predominantly in the ovary.

Long Name

Forkhead Box L2

Alternate Names

BPES, BPES1, PFRK, PINTO, POF3

Entrez Gene IDs

26927 (Mouse)

Gene Symbol

FOXL2

Product Documents for FOXL2 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for FOXL2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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