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Factor XII heavy chain Antibody (4E7) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-46534

Novus Biologicals, part of Bio-Techne
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NBP3-46534

Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunohistochemistry, Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 4E7

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

coagulation factor XII(Hageman factor). (Uniprot# P00748)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

28 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

Novus Biologicals Mouse Factor XII heavy chain Antibody (4E7) - BSA Free (NBP3-46534) is a monoclonal antibody validated for use in IHC, WB, ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for Factor XII heavy chain Antibody (4E7) - BSA Free

Factor XII heavy chain Antibody (4E7) - BSA Free

Immunohistochemistry: Factor XII heavy chain Antibody (4E7) - BSA Free [NBP3-46534] -

Immunohistochemistry: Factor XII heavy chain Antibody (4E7) - BSA Free [NBP3-46534] - Immunohistochemistry of paraffin-embedded human liver tissue slide using (Factor XII heavy chain Antibody) at dilution of 1:200
Factor XII heavy chain Antibody (4E7) - BSA Free

Western Blot: Factor XII heavy chain Antibody (4E7) - BSA Free [NBP3-46534] -

Western Blot: Factor XII heavy chain Antibody (4E7) - BSA Free [NBP3-46534] - K-562 cells were subjected to SDS PAGE followed by western blot with (Factor XII heavy chain antibody) at dilution of 1:1000

Applications for Factor XII heavy chain Antibody (4E7) - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:500

Immunohistochemistry

1:50-1:500

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS, 50% Glycerol, pH (7.3)

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Factor XII heavy chain

The F12 gene encodes a 615 amino acid long, 67 kDA serum glycoprotein coagulation factor XII that is eventually cleaved into four chains. Factor XII functions in the initiation of blood coagulation, fibrinolysis, as well as in the creation of bradykinin and angiotension. F12 participates in cell adhesion plasmin signaling, blood coagulation signaling pathways, MSP-RON signaling, intrinsic prothrombin activation pathways, and blood clotting cascades. It interacts with Genes CD93, MMP13, EPAS1, APP, and KLKB1. Defects in F12 lead to factor Xii deficiency (Hageman factor deficiency) as well as hereditary angioedema type 3 (estrogen-related HAE). F12 is also associated with blood clots, acute myocardial infarction, thrombosis, spastic paraplegia, angiodema, retinal vein occlusion, arterial calcification, heart disease, C1 inhibitor deficiency, hemorrhagic disease, and acalculous cholecystitis.

Alternate Names

beta-factor XIIa part 1, coagulation factor XII, coagulation factor XII (Hageman factor), coagulation factor XIIa heavy chain, coagulation factor XIIa light chain, EC 3.4.21, EC 3.4.21.38, HAE3, HAEX, HAFbeta-factor XIIa part 2, Hageman factor

Gene Symbol

F12

Additional Factor XII heavy chain Products

Product Documents for Factor XII heavy chain Antibody (4E7) - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Factor XII heavy chain Antibody (4E7) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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