Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Janelia Fluor 646

Antibody Source

Polyclonal Goat IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all DR3/TNFRSF25 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human DR3/TNFRSF25
Gln25-Phe201
Accession # Q93038

Specificity

Detects human DR3/TNFRSF25 in direct ELISAs and Western blots. In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse DR3 is observed, and less than 1% cross‑reactivity with recombinant human (rh) Fas, rhTNF RI, rhDR6, rh4-1BB, rhCD27, rhCD30, rhCD40, rhGITR, rhHVEM, rhTNF RII and rhOPG is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for DR3/TNFRSF25 Antibody [Janelia Fluor® 646]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: DR3/TNFRSF25

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family, through their death domain containing receptors TNFR1 and Fas. A cell surface receptor with a death domain, DR3, has been identified by several groups independently, although it has been given alternative names. The ligand for DR3 has very recently been identified as TWEAK, also termed Apo3L. DR3 is highly expressed in tissues enriched in lymphocytes including PBL, thymus and spleen. DR3 mediates activation of NF kappa B, and induces apoptosis. DR3 may also play a role in regulating lymphocyte homeostasis.

Long Name

Death Receptor 3

Alternate Names

Apo-3, LARD, TNFRSF25, TRAMP, WSL-1

Gene Symbol

TNFRSF25

Additional DR3/TNFRSF25 Products

Product Documents for DR3/TNFRSF25 Antibody [Janelia Fluor® 646]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for DR3/TNFRSF25 Antibody [Janelia Fluor® 646]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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