DNA Polymerase gamma Antibody (24GB1085)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51483

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NBP3-51483-100ul
NBP3-51483-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB1085

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all DNA Polymerase gamma Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human DNA Polymerase gamma (Uniprot: P54098)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DNA Polymerase gamma Antibody (24GB1085)

DNA Polymerase gamma Antibody (24GB1085)

Immunocytochemistry/ Immunofluorescence: DNA Polymerase gamma Antibody (24GB1085)[NBP3-51483] -

Immunocytochemical staining of HeLa cells with DNA Polymerase gamma antibody (1:1,000). Nuclei were stained blue with DAPI; DNA Polymerase gamma was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain:Medium . Scale bar, 20 um.
DNA Polymerase gamma Antibody (24GB1085)

Flow Cytometry: DNA Polymerase gamma Antibody (24GB1085)[NBP3-51483] -

Flow cytometric analysis of DNA Polymerase gammaexpression in HeLa cells using DNA Polymerase gamma antibody (1:2,000). Green, isotype control; red, POLG.
DNA Polymerase gamma Antibody (24GB1085)

Western Blot: DNA Polymerase gamma Antibody (24GB1085)[NBP3-51483] -

Western blotting analysis using DNA Polymerase gamma antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using NaQ(TM) ECL Substrate Kit.

Applications for DNA Polymerase gamma Antibody (24GB1085)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: DNA Polymerase gamma

As the only DNA polymerase (pol) present in mitochondria, DNA polymerase gamma (POLG) is necessarily implicated in base excision repair processes to correct oxidative damage to the mitochondrial genome. Therefore, the ability of the catalytic subunit of human POLG has been tested to participate in uracil-provoked base excision repair reconstituted in vitro with purified components. Subsequent to actions of uracil-DNA glycosylase and apurinic/apyrimidinic endonuclease, human POLG is able to fill a single nucleotide gap in the presence of a 5' terminal deoxyribose phosphate (dRP) flap. The catalytic subunit of human pol gamma catalyzes release of the dRP residue from incised apurinic/apyrimidinic sites to produce a substrate for DNA ligase. Faulty replication of the human mitochondrial genome is thought to be the cause of many diseases. The low selectivity of the mitochondrial DNA polymerase is implicated as the cause of many side effects observed in the treatment of viral infections such as HIV.

Long Name

DNA polymerase subunit gamma-1

Alternate Names

MDP1, POLG, PolG-alpha, POLG1, POLGA

Gene Symbol

POLG

Additional DNA Polymerase gamma Products

Product Documents for DNA Polymerase gamma Antibody (24GB1085)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DNA Polymerase gamma Antibody (24GB1085)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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