Pleckstrin homology, Sec7 and coiled/coil domains 2 (PSCD2) is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. PSCD2 exhibits GEP activity in vitro with ARF1, ARF3, and ARF6. PSCD2 protein is 83% homologous to PSCD1. Two transcript variants encoding different isoforms have been found for this gene.

Long Name

Cytohesin-2

Alternate Names

ARF exchange factor, ARNO, CYTH2, Protein ARNO, PSCD2, PSCD2L

Gene Symbol

Cytohesin 2, CYTH2

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Product Documents for Cytohesin 2 Antibody (OTI4D9) [Janelia Fluor® 549]

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Product Specific Notices for Cytohesin 2 Antibody (OTI4D9) [Janelia Fluor® 549]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Cytohesin 2 Antibody (OTI4D9) [Janelia Fluor® 549]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-44710JF549

Key Product Details

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Applications for Cytohesin 2 Antibody (OTI4D9) [Janelia Fluor® 549]

Immunohistochemistry

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Background: Cytohesin 2