Cyclophilin 40 Antibody (24GB1560)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51525

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NBP3-51525-100ul
NBP3-51525-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB1560

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Cyclophilin 40 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Cyclophilin 40 (Uniprot: Q08752)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Cyclophilin 40 Antibody (24GB1560)

Cyclophilin 40 Antibody (24GB1560)

Immunocytochemistry/ Immunofluorescence: Cyclophilin 40 Antibody (24GB1560)[NBP3-51525] -

Cyclophilin 40 antibody (1:1,000), Top panel: wild-type (WT); Bottom panal: Peptidylprolyl isomerase D shRNA knockdown (KD). Nuclei were stained blue with DAPI; Peptidylprolyl isomerase D was stained magenta with Alexa Fluor(R) 647. Scale bar, 20 um. Permeabilization: Triton.
Cyclophilin 40 Antibody (24GB1560)

Immunocytochemistry/ Immunofluorescence: Cyclophilin 40 Antibody (24GB1560)[NBP3-51525] -

Immunocytochemical staining of HepG2 cells with Cyclophilin 40 antibody (1:1,000). Nuclei were stained blue with DAPI; Cyclophilin 40 was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 um.
Cyclophilin 40 Antibody (24GB1560)

Flow Cytometry: Cyclophilin 40 Antibody (24GB1560)[NBP3-51525] -

Validation of Cyclophilin 40 knockdown using flow cytometry. Wild-type(WT, Blue) and knockdown(KD, Green) HeLa cells were stained with Cyclophilin 40 antibody (1:2,000) and analyzed using BD flow cytometer.
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Applications for Cyclophilin 40 Antibody (24GB1560)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Cyclophilin 40

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents: cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. CyP 40, a 40 kDa protein, shares significant homology with smaller CyPA (CyP 18) and FKBP59. CyP 40 exhibits the characteristic CsA binding and isomerase activity of CyP 18, though these activities appear to be less with CyP 40 than with Cyp 18. Like FKBP59, CyP 40 has been found in progesterone receptor complexes. CyP 40 is expressed at similar levels in many tissues.

Alternate Names

40 kDa peptidyl-prolyl cis-trans isomerase, 40 kDa peptidyl-prolyl cis-trans isomerase D, cyclophilin D, Cyclophilin-40, Cyclophilin-related protein, CYP40, CYP-40cyclophilin 40, CYPD, EC 5.2.1.8, MGC33096, peptidyl-prolyl cis-trans isomerase D, peptidylprolyl isomerase D, peptidylprolyl isomerase D (cyclophilin D), PPIase D, Rotamase D

Gene Symbol

PPID

Additional Cyclophilin 40 Products

Product Documents for Cyclophilin 40 Antibody (24GB1560)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Cyclophilin 40 Antibody (24GB1560)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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