Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. The transcript variants are formed through the use of alternative translation initiation sites and promoters.

Long Name

Catechol O-Methyltransferase

Alternate Names

catechol O-methyltransferase, catechol-O-methyltransferase, EC 2.1.1.6

Gene Symbol

COMT

Additional COMT Products

Product Documents for COMT Antibody [Dylight 550]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for COMT Antibody [Dylight 550]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

COMT Antibody [Dylight 550]

Novus Biologicals, part of Bio-Techne | Catalog # AF7386L

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

Concentration

View all COMT Antibodies »

Product Specifications

Immunogen

Specificity

Clonality

Host

Isotype

Applications for COMT Antibody [Dylight 550]

Western Blot

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: COMT