CCL4/MIP-1 beta Antibody (46907) [DyLight 350]
Novus Biologicals, part of Bio-Techne | Catalog # FAB451D
Conjugate
Catalog #
Key Product Details
Species Reactivity
Mouse
Applications
Neutralization
Label
DyLight 350 (Excitation = 353 nm, Emission = 432 nm)
Antibody Source
Monoclonal Rat IgG2A Clone # 46907
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
E. coli-derived recombinant mouse CCL4/MIP-1 beta
Ala24-Asn92
Accession # Q5QNV9
Ala24-Asn92
Accession # Q5QNV9
Specificity
Detects mouse CCL4/MIP-1 beta in ELISAs. Does not cross-react with recombinant human (rh) CCL1, 2, 4/MIP-1 alpha, 4/MIP-1 beta, 5, 7, 8, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22,
23, 24, 25, 26, rmCCL1, 2, 4/MIP-1 alpha, 4/MIP-1 beta, 5, 6, 7, 9/10, 11, 12, 17, 19, 20, 21, 22, 24, 25, or rrCCL20.
Clonality
Monoclonal
Host
Rat
Isotype
IgG2A
Applications for CCL4/MIP-1 beta Antibody (46907) [DyLight 350]
Application
Recommended Usage
Neutralization
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: CCL4/MIP-1 beta
CCL4/MIP-1 beta is a beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells. It attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium. CCL4 is secreted from activated monocytes as a heterodimer with CCL3/MIP-1 alpha. It signals through CCR5, and an N-terminally trimmed form additionally interacts with CCR1 and CCR2. In humans, the ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV-1 which utilizes CCR5 as a coreceptor.
Alternate Names
Exodus-3, MIP-1 beta, MIP1 beta
Gene Symbol
CCL4
Additional CCL4/MIP-1 beta Products
Product Documents for CCL4/MIP-1 beta Antibody (46907) [DyLight 350]
Product Specific Notices for CCL4/MIP-1 beta Antibody (46907) [DyLight 350]
DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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