BMP-15/GDF-9B Antibody (BMP15/4263) [DyLight 488]
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08876G
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot, ELISA
Label
DyLight 488 (Excitation = 493 nm, Emission = 518 nm)
Antibody Source
Monoclonal Mouse IgG1 Clone # BMP15/4263
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Recognizes sequence SAEVTASSSKHSGPENNQC on the C-terminus of human BMP-15/GDF-9B (Uniprot: O95972)
Localization
Cytoplasmic (secreted)
Specificity
BMP15, also known as GDF9B, plays a crucial role in the regulation of fertility. Clone BMP15/4263 can be used to detect BMP15 expression and biosynthesis in various carcinoma progression studies.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Description
This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
Applications for BMP-15/GDF-9B Antibody (BMP15/4263) [DyLight 488]
Application
Recommended Usage
ELISA
Optimal dilutions of this antibody should be experimentally determined.
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Recommended applications are based on validated applications from the unconjugated base product NBP3-08876. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: BMP-15/GDF-9B
BMP-15 (Bone morphogenetic protein 15), also known as GDF-9B, is a TGF-b superfamily ligand that is expressed by oocytes throughout folliculogenesis and plays an important role in oocyte development. BMP-15 promotes the FSH-independent proliferation of ovarian granulosa cells (GC) and induces GC glycolysis and cholesterol synthesis. BMP-15 blocks the FSH-induced GC expression of FSH R and multiple steroidogenic molecules. BMP-15 exerts is effects through interactions with BMPR-IB/ALK6 and BMPR-II, and nonphosphorylated BMP-15 functions as a competitive antagonist at BMPR-IB. Mature BMP-15 forms 34 kDa noncovalently-linked homodimers and 37 kDa heterodimers with mature GDF-9.
Long Name
Bone Morphogenetic Protein 15
Alternate Names
BMP15, GDF-9B
Gene Symbol
BMP15
Additional BMP-15/GDF-9B Products
Product Documents for BMP-15/GDF-9B Antibody (BMP15/4263) [DyLight 488]
Product Specific Notices for BMP-15/GDF-9B Antibody (BMP15/4263) [DyLight 488]
DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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