beta-Arrestin 1 [p Ser412] Antibody (23GB3845)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51231

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NBP3-51231-100ul
NBP3-51231-20ul
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 23GB3845

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all beta-Arrestin 1 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Phospho-beta-Arrestin 1 (S412) (Uniprot: P49407)

Modification

p Ser412

Specificity

This antibody detects endogenous levels of ARRB1 only when phosphorylated at S412

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Applications for beta-Arrestin 1 [p Ser412] Antibody (23GB3845)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: beta-Arrestin 1

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization ofG-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones,neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in thebeta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the centralnervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin systemis believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcriptsencoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.(provided by RefSeq)

Alternate Names

ARR1, ARRB1, betaArrestin 1

Gene Symbol

ARRB1

Additional beta-Arrestin 1 Products

Product Documents for beta-Arrestin 1 [p Ser412] Antibody (23GB3845)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for beta-Arrestin 1 [p Ser412] Antibody (23GB3845)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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