Bcl-xL Antibody (23GB3000)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51072

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NBP3-51072-100ul
NBP3-51072-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 23GB3000

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Bcl-xL Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Bcl-xL (Uniprot: Q07817)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Bcl-xL Antibody (23GB3000)

Bcl-xL Antibody (23GB3000)

Immunocytochemistry/ Immunofluorescence: Bcl-xL Antibody (23GB3000)[NBP3-51072] -

Immunocytochemical staining of HT-1080 cells with Bcl-xL antibody (1:1,000). Nuclei were stained blue with DAPI; Bcl-xL was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 um.
Bcl-xL Antibody (23GB3000)

Flow Cytometry: Bcl-xL Antibody (23GB3000)[NBP3-51072] -

Validation of Bcl-xL knockdown using flow cytometry. Wild-type(WT, Blue) and knockdown(KD, Green) HeLa cells were stained with Bcl-xL antibody (1:2,000) and analyzed using CytoFLEX.
Bcl-xL Antibody (23GB3000)

Flow Cytometry: Bcl-xL Antibody (23GB3000)[NBP3-51072] -

Flow cytometric analysis of Bcl-xLexpression in HT-1080 cells using Bcl-xL antibody (1:2,000). Green, isotype control; red, Bcl-XL.
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Applications for Bcl-xL Antibody (23GB3000)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Bcl-xL

Bcl-x, a member of the Bcl-2 protein family, inhibits cell death, or apoptosis (1). Bcl-x is expressed as two isomeric forms, Bcl-xL and Bcl-xS, and is typically present in the cytosol in association with the mitochondrial membrane. Bcl-xL forms heterodimers with various proteins, including Bax, Bak and Bcl-2 (2). It has been found that eterodimerization with Bax does not seem to be required for anti-apoptotic activity (3). Since Bcl-xL can form an ion channel in synthetic lipid membranes, there is a strong possibility that this property plays a role in heterodimerization-independent cell survival (4). The Bcl-X(S) isoform promotes apoptosis.

Long Name

B Cell Lymphoma/Leukemia x Long Form

Alternate Names

BclxL

Gene Symbol

BCL2L1

Additional Bcl-xL Products

Product Documents for Bcl-xL Antibody (23GB3000)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Bcl-xL Antibody (23GB3000)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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