Apolipoprotein E (APOE) is an apolipoprotein located in chylomicrons and intermediate-density lipoproteins that is necessary for the normal catabolism of triglyceride-rich lipoprotein constituents in the liver. APOE has recently been shown to be involseveral biological processes other than lipoprotein transport, including cognition and immunoregulation.

Lipoproteins are responsible for carrying cholesterol and other fats through the bloodstream as little packages and are essential for the normal breakdown of these molecules. In particular, apolipoprotein E is a major component of very low-density lipoproteins (VLDL), which remove excess cholesterol from the blood and carry it to the liver for processing. Maintaining normal levels of cholesterol is essential for the prevention of cardiovascular diseases, including heart attacks and strokes.

There are three known Apo E isoforms (ApoE2, E3 and E4), which are strongly associated with cardiovascular disease and/orAlzheimer's disease. Therefore, ApoE antibodies have become useful tools for research in both of these areas.

Long Name

Apolipoprotein E4

Alternate Names

Apo-E, apolipoprotein E, apolipoprotein E3, late onset), LDLCQ5, MGC1571

Gene Symbol

APOE

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Product Documents for ApoE4 Antibody (4E4) [Alexa Fluor™ Plus 680]

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SDS

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Product Specific Notices for ApoE4 Antibody (4E4) [Alexa Fluor™ Plus 680]

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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ApoE4 Antibody (4E4) [Alexa Fluor™ Plus 680]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-49529AFP680

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

Concentration

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Product Specifications

Immunogen

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Clonality

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Isotype

Applications for ApoE4 Antibody (4E4) [Alexa Fluor™ Plus 680]

ELISA

Immunocytochemistry/ Immunofluorescence

Immunoprecipitation

Western Blot

Formulation, Preparation, and Storage

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Shipping

Stability & Storage

Background: ApoE4