APIP Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56383

Novus Biologicals, part of Bio-Techne
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NB100-56383
NB100-56383SS
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

0.5 mg/ml

View all APIP Antibodies »

Product Specifications

Immunogen

The antibody was developed against a full-length His-tagged recombinant APIP protein (NP_057041).

Specificity

This polyclonal can be used for detection of APIP and APIP2.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for APIP Antibody - BSA Free

Western Blot: APIP Antibody [NB100-56383]

Western Blot: APIP Antibody [NB100-56383]

Western Blot: APIP Antibody [NB100-56383] - Analysis of APIP 2 in human muscle using this antibody at 2 ug/ml.
Immunohistochemistry-Paraffin: APIP Antibody [NB100-56383]

Immunohistochemistry-Paraffin: APIP Antibody [NB100-56383]

Immunohistochemistry-Paraffin: APIP Antibody [NB100-56383] - Formalin-fixed, paraffin-embedded human kidney tissue probed with this antibody at 5 ug/ml.

Applications for APIP Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: APIP

The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1) (1,2). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Recently, Cho et al (4) have identified a new Apaf-1 Interacting Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.

Alternate Names

APAF1 interacting protein, APAF1-interacting protein, APIP2, CGI29, CGI-29, dJ179L10.2, EC 4.2.1.109, MMRP19, MTRu-1-P dehydratase, probable methylthioribulose-1-phosphate dehydratase

Entrez Gene IDs

51074 (Human)

Gene Symbol

APIP

UniProt

Q96GX9 (Human)

Additional APIP Products

Product Documents for APIP Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for APIP Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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