ADAM10 Antibody (CL13815) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-24580

Novus Biologicals, part of Bio-Techne
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Conjugate
Catalog #
Alexa Fluor 350
NBP3-43827AF350
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Alexa Fluor 405
NBP3-43827AF405
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Alexa Fluor 488
NBP3-43827AF488
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Alexa Fluor 532
NBP3-43827AF532
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Alexa Fluor 594
NBP3-43827AF594
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Alexa Fluor 647
NBP3-43827AF647
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Alexa Fluor 700
NBP3-43827AF700
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Alexa Fluor 750
NBP3-43827AF750
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Alexa Fluor Plus 488
NBP3-43827AFP488
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Alexa Fluor Plus 555
NBP3-43827AFP555
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Alexa Fluor Plus 594
NBP3-43827AFP594
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Alexa Fluor Plus 647
NBP3-43827AFP647
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Alexa Fluor Plus 680
NBP3-43827AFP680
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Allophycocyanin
NBP3-43827APC
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Biotin
NBP3-43827B
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CoraFluor 1
NBP3-43827CL1
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DyLight 350
NBP3-43827UV
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DyLight 405
NBP3-43827V
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DyLight 488
NBP3-43827G
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DyLight 550
NBP3-43827R
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DyLight 594
NBP3-43827DL594
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DyLight 650
NBP3-43827C
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DyLight 680
NBP3-43827FR
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DyLight 755
NBP3-43827IR
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FITC
NBP3-43827F
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HRP
NBP3-43827H
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Janelia Fluor 525
NBP3-43827JF525
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Janelia Fluor 549
NBP3-43827JF549
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Janelia Fluor 646
NBP3-43827JF646
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Janelia Fluor 669
NBP3-43827JF669
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mFluor Violet 450 SE
NBP3-43827MFV450
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mFluor Violet 500 SE
NBP3-43827MFV500
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mFluor Violet 610 SE
NBP3-43827MFV610
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PE
NBP3-43827PE
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PerCP
NBP3-43827PCP
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # CL13815

Format

BSA Free

Concentration

1 mg/ml

View all ADAM10 Antibodies »

Product Specifications

Immunogen

This antibody was developed using a synthetic peptide derived from O14672, with the exact immunogen sequence remaining proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for ADAM10 Antibody (CL13815) - BSA Free

Immunohistochemistry-Paraffin: ADAM10 Antibody (CL13815) [NBP3-24580]

Staining of human fallopian tube shows strong membranous and cytoplasmic positivity in glandular cells.

Immunohistochemistry-Paraffin: ADAM10 Antibody (CL13815) [NBP3-24580]

Staining of human anaplastic oligodendroglioma shows strong cytoplasmic positivity in tumor cells.

Immunohistochemistry-Paraffin: ADAM10 Antibody (CL13815) [NBP3-24580]

Staining of human cerebral cortex shows moderate to strong cytoplasmic positivity in neurons.
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Applications for ADAM10 Antibody (CL13815) - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

2-10 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, we recommend using Heat-Induced Epitope Retrieval (HIER) with a pH level of 6. This optimized retrieval method ensures the best results for your experiments, For ICC/IF, we recommend using a combination of PFA and Triton X-100. This will give you the optimal results for your experiments.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ADAM10

Proinflammatory cytokine tumor necrosis factor-alpha (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively, (1,2,4). ADAM10 mRNA is expressed in a variety of human and bovine tissues (1,4).

Long Name

A Disintegrin and Metalloprotease-like Domain 10

Alternate Names

CD156c, Kuzbanian, MADM

Gene Symbol

ADAM10

Additional ADAM10 Products

Product Documents for ADAM10 Antibody (CL13815) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ADAM10 Antibody (CL13815) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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