Acetyl-CoA Carboxylase alpha/ACACA [p Ser79] Antibody (SR1413) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21598

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1413

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Acetyl-CoA Carboxylase alpha/ACACA Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human phospho-Acetyl-CoA Carboxylase alpha/ACACA [Ser79] (Uniprot #: Q13085)

Modification

p Ser 79

Specificity

Detects endogenous levels of total phospho-Acetyl-CoA Carboxylase alpha/ACACA[Ser79]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

265 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images

Western Blot: Acetyl-CoA Carboxylase alpha/ACACA [p Ser 79] Antibody (SR1413) [NBP3-21598] -

Western Blot: Acetyl-CoA Carboxylase alpha/ACACA [p Ser 79] Antibody (SR1413) [NBP3-21598] - Western blot analysis using NBP3-21598 in (1) A431 cell lysate; (2) A431 cell treated with lambda phosphatase lysate.

Applications

Application
Recommended Usage

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Acetyl-CoA Carboxylase alpha/ACACA

Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).

Long Name

Acetyl-Coenzyme A Carboxylase alpha

Alternate Names

ACACA, ACC1, ACCA, AcetylCoA Carboxylase alpha

Gene Symbol

ACACA

Additional Acetyl-CoA Carboxylase alpha/ACACA Products

Product Documents

Product Datasheets

Certificate of Analysis

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Product Specific Notices

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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