Acetyl-CoA Carboxylase alpha/ACACA Antibody (23GB5645)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51364

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NBP3-51364-100ul
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 23GB5645

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Acetyl-CoA Carboxylase alpha/ACACA Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Acetyl-CoA Carboxylase alpha/ACACA (Uniprot: Q13085)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Acetyl-CoA Carboxylase alpha/ACACA Antibody (23GB5645)

Acetyl-CoA Carboxylase alpha/ACACA Antibody (23GB5645)

Immunocytochemistry/ Immunofluorescence: Acetyl-CoA Carboxylase alpha/ACACA Antibody (23GB5645)[NBP3-51364] -

Immunocytochemical staining of HepG2 cells with Acetyl-CoA Carboxylase alpha/ACACA antibody (1:1,000) . Nuclei were stained blue with DAPI; Acetyl-CoA Carboxylase alpha/ACACA was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 um.
Acetyl-CoA Carboxylase alpha/ACACA Antibody (23GB5645)

Flow Cytometry: Acetyl-CoA Carboxylase alpha/ACACA Antibody (23GB5645)[NBP3-51364] -

Flow cytometric analysis of Acetyl-CoA Carboxylase alpha/ACACAexpression in HepG2 cells using Acetyl-CoA Carboxylase alpha/ACACA antibody (1:2,000). Green, isotype control; red, Acetyl-CoA carboxylase alpha.

Applications for Acetyl-CoA Carboxylase alpha/ACACA Antibody (23GB5645)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Acetyl-CoA Carboxylase alpha/ACACA

Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).

Long Name

Acetyl-Coenzyme A Carboxylase alpha

Alternate Names

ACACA, ACC1, ACCA, AcetylCoA Carboxylase alpha

Gene Symbol

ACACA

Additional Acetyl-CoA Carboxylase alpha/ACACA Products

Product Documents for Acetyl-CoA Carboxylase alpha/ACACA Antibody (23GB5645)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Acetyl-CoA Carboxylase alpha/ACACA Antibody (23GB5645)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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