Abeta 40 Antibody (3D7) - Chimeric
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-48386
Recombinant Monoclonal Antibody
Key Product Details
Species Reactivity
Human
Applications
Flow Cytometry
Label
Unconjugated
Antibody Source
Recombinant Monoclonal Human IgG1 Clone # 3D7
Concentration
LYOPH mg/ml
Product Specifications
Immunogen
Abeta 40 recombinant protein expressed in mammalian cells (Accession# P05067). The exact amino acid sequence is proprietary.
Clonality
Monoclonal
Host
Human
Isotype
IgG1
Description
This product is shipped at ambient temperature. Store at -20C to -80C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80C (Avoid repeated freezing and thawing).
Scientific Data Images for Abeta 40 Antibody (3D7) - Chimeric
Flow Cytometry: Abeta 40 Antibody (3D7) - Chimeric [NBP3-48386]
Flow cytometry analysis of antigen binding of anti-human APP mAb(NBP3-48386). (A) NBP3-48386 does not bind to CHO-S cells that do not express APP. (B) A clear peak shift of NBP3-48386 was seen compared to the control when incubated with APP-expressing Siha cells, indicating strong binding of NBP3-48386 to APP. Antibodies were incubated at 5 ug/mL.
Flow Cytometry: Abeta 40 Antibody (3D7) - Chimeric [NBP3-48386]
Flow cytometry analysis with Anti-Abeta 40 (3D7) mAb on HEK293 cells transfected with human Abeta 40 (Blue histogram) or HEK293 transfected with irrelevant protein (Red histogram).Applications for Abeta 40 Antibody (3D7) - Chimeric
Application
Recommended Usage
Flow Cytometry
1:100
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified from cell culture supernatant
Reconstitution
Dissolve the lyophilized antibody in sterile and low endotoxin water. The recommend volume of water is lot specific. Please refer to the instructions printed on the product vial or contact technical support.
Formulation
PBS, pH 7.4, 5-8% Trehalose
Preservative
Trehalose
Concentration
LYOPH mg/ml
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at -20C in powder form. Store at -80C once reconstituted.
Background: Abeta 40
The Amyloid beta A4 protein (Abeta40) is the more common isoform and is the main components of amyloid plaques. Abeta-40 is produced by cleavage of the Amyloid Precursor Protein (APP) that occurs in the endoplasmic reticulum.
The Amyloid beta proteins function as a cell surface receptor and supports neurite growth, neuronal adhesion and axonogenesis on the surface of neurons. Amyloid betas are also involved in cell mobility functions and transcription regulation via various protein-protein interactions.
Abeta40 antibodies are useful tools for Alzheimer's studies and research on amyloid plaques.
Alternate Names
amyloid beta 40, Beta-amyloid protein 40
Gene Symbol
APP
Additional Abeta 40 Products
Product Documents for Abeta 40 Antibody (3D7) - Chimeric
Product Specific Notices for Abeta 40 Antibody (3D7) - Chimeric
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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