Wnt-5b Proteins and Enzymes

Wnt-5b is a 49 kDa glycoprotein of the subgroup of Wnts that is implicated in the non-canonical Wnt/Ca²⁺ pathway. Wnt-5b is not axis-inducing in Xenopus embryos and only weakly transforms C57MG mammary epithelial cells. In adult mice, Wnt-5b is expressed in heart, liver, brain, lung, testes, kidney, and pancreas. Wnt-5b appears to promote adipogenesis and is upregulated in early adipogenesis. Also, Wnt-5b overexpression in 3T3-L1 cells partially inhibits canonical Wnt suppression of ...