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UNC5H2/UNC5B Products
UNC5H2/UNC5B is a transmembrane molecule that mediates axon repulsion and growth cone collapse through interactions with Netrin, Neogenin, and FLRT3. Its association with DCC switches the DCC-Netrin-1 response from attraction to repulsion. Outside the nervous system, UNC5H2 facilitates Netrin-1-mediated inhibition of capillary branching and leukocyte migration as well as Netrin-1-mediated promotion of osteoclast differentiation. It is downregulated in multiple cancers and inhibits tumor cell growth and invasion. It also plays a critical role in the development of atherosclerosis and the survival of renal tubular epithelial cells during acute kidney injury.
6 results for "UNC5H2/UNC5B" in Products
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UNC5H2/UNC5B Products
UNC5H2/UNC5B is a transmembrane molecule that mediates axon repulsion and growth cone collapse through interactions with Netrin, Neogenin, and FLRT3. Its association with DCC switches the DCC-Netrin-1 response from attraction to repulsion. Outside the nervous system, UNC5H2 facilitates Netrin-1-mediated inhibition of capillary branching and leukocyte migration as well as Netrin-1-mediated promotion of osteoclast differentiation. It is downregulated in multiple cancers and inhibits tumor cell growth and invasion. It also plays a critical role in the development of atherosclerosis and the survival of renal tubular epithelial cells during acute kidney injury.
6 results for "UNC5H2/UNC5B" in Products
Catalog #:
1006-UN
Bind
| Source : | NS0 |
| Accession # : | O08722 |
| Applications : | Binding Activity |
WB, IHC
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunohistochemistry, Western Blot |
Catalog #:
MAB1006
WB
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #187305 |
| Applications : | Western Blot |
Catalog #:
BAF1006
WB, IHC
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunohistochemistry, Western Blot |
Catalog #:
8869-UN
BA
| Source : | CHO |
| Accession # : | Q8IZJ1 |
| Applications : | Bioactivity |
