Somatostatin Receptor Antagonists: Small Molecules and Peptides

Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation. The somatostatin receptor family consists of five subtypes, sst_1-5, each differentially distributed throughout the central nervous system and periphery. Endogenous somatostatin receptor ligands include somatostatin-14 and ...